Medicine has always focused on treating disease after it occurs, with both treatment and diagnosis based largely on population averages.

We are now poised to transition to a new medical paradigm that is Predictive, Preventive, Personalized, and Participatory (P4).



P4 medical care is an ongoing, data-driven journey to health involving all aspects of your life, your environment, your mind and your body.



P4 Medicine—predictive, preventive, personalized, and participatory—is a new kind of medical practice that complements and augments the existing disease-care system. It provides patients with a physician guide to medical science as a tool for living healthier, happier, and more productive lives.



Systems Biology was pioneered in the early 2000s by P4Mi’s Founder and Board Chair, Leroy Hood, along with scientists at the Institute for Systems Biology in Seattle, Washington. Today, major universities and research institutes all over the world teach and practice systems biology.

Systems biologists think of biology as integrated systems of networks operating at the levels of molecules, cells, organs, and even social interactions among people. All of these networks, including your genes and your environment, interact to effect health. Visit https://systemsbiology.org/about/what-is-systems-biology/ for more.

P4 Medicine is the clinical expression of a holistic approach to biology— systems biology —that is rigorously quantified using cutting-edge, digital-age technologies and scientific paradigms.


The ultimate goal of P4 medical care is to know yourself, for knowledge is power. In the case of P4 Medicine, it is power to predict and prevent disease, to feel good, to slow or even partially reverse biological aging, and to optimize your ability to move, think, and perform at your best in all aspects of your life.


P4 medical care is highly personalized, recognizing that people respond very differently to lifestyle factors such as food, activity, and sleep, as well as to drugs and other types of medical interventions. These reactions cannot effectively be inferred from population averages. That is why P4Mi’s medical programs focus on using the latest technologies to construct a dynamic personal data cloud for each individual patient as the basis for care.


P4 medical care is highly participatory. It requires patients to work with their physician to understand their health status and how it is affected by their lifestyle and environment. Patients are experts in their own lives. At P4Mi, this expertise is central to the design of experiments used to discover and validate the best health solutions for unique individuals.


Without P4 medical guidance, people seeking to enhance and protect their health are faced with making wholesale lifestyle changes in the dark, based on population averages that often don’t apply to them. By harnessing the power of personalized actionable information, P4 patients can make highly targeted, practical, and sustainable adjustments they know work for them.